专家介绍
        • 姓名: 陈茂根
        • 浏览次数: 264

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        陈茂根

        中山大学附属第一医院器官移植科,住院医师,医学博士。

        受教育经历(从大学本科开始,按时间倒排序)

        2008/09-2013/06,中山大学,附属第一医院器官移植外科,博士

        2005/09-2008/07,汕头大学医学院,第二附属医院普通外科,硕士

        2000/09-2005/07,赣南医学院,临床医学系,学士

        研究工作经历(按时间倒排序)

        2013/07-        中山大学附属第一医院器官移植科,住院医师

        2010/11-2013/01,美国南加州大学,免疫系,博士后研究   

        2009/03-2010/03,中山大学,附属第一医院器官移植外科,博士研究生实习医师

        2006/08-2008/08,汕头大学医学院,第二附属医院普通外科,硕士研究生实习医师

        2004/03-2005/04,赣南医学院,第一附属医院,本科生实习医师

        主要论著(近5年来已发表的与本项目有关的主要论著目录和获得学术奖励情况)

        一、期刊论文

        发表SCI文章第一作者(共同第一作者)6篇,参与发表SCI论著9篇。

        1.      Chen M, Lin X, Liu Y, Li Q, Deng Y, Liu Z, Brand D, Guo Z, He X, Ryffel B, Zheng SG. The function of BAFF on T helper cells in autoimmunity. Cytokine Growth Factor Rev. 2013 Dec 24. pii: S1359-6101(13)00109-3. doi: 10.1016/j.cytogfr.2013.12.011.   (IF=8.831)

        2.      Horwitz DA, Pan S, Ou JN, Wang J, Chen M, Gray JD, Zheng SG. Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo. Clin Immunol. 2013 Dec;149(3):450-63.     (IF=3.771)

        3.      Liu Y, Lan Q, Lu L, Chen M, Xia Z, Ma J, Wang J, Fan H, Shen Y, Ryffel B, Brand D, Quismorio F, Liu Z, Horwitz DA, Xu A, Zheng SG. Phenotypic and functional characteristic of a newly identified CD8+Foxp3-CD103+ regulatory T cells. J Mol Cell Biol. 2013 Sep 7. [Epub ahead of print]   (IF=7.308)

        4.      Zhang C, Liao Y, Li Q, Chen M, Zhao Q, Deng R, Wu C, Yang A, Guo Z, Wang D, He X. Recombinant Adiponectin Ameliorates Liver Ischemia Reperfusion Injury via Activating the AMPK/eNOS Pathway.PLoS One. 2013 Jun 7;8(6):e66382.    (IF=3.73)

        5.      Chen M, Su W, Lin X, Guo Z, Wang J, Zhang Q, Brand D, Ryffel B, Huang J, Liu Z, He X, Le AD, Zheng SG. Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. Arthritis Rheum. 2013 May; 65(5):1181-93.   (IF=7.74)

        6.      Lin X, Chen M(共同作者), Liu Y, Guo Z, He X*, Brand D, Zheng SG*. Advances in distinguishing natural from induced Foxp3+ regulatory T cells. Int J Clin Exp Pathol 2013;6(2): 116-123   (IF=2.242)

        7.      Ju W, Chen M (共同作者), Guo Z, Wang D, Zhu X, Huang J, He X*. Allografts Positive for Hepatitis B Surface Antigen in Liver Transplant for Disease Related to Hepatitis B Virus. Exp Clin Transplant. 2013 Jun;11(3):245-9.    (IF=0.588)

        8.      Kong N, Lan Q,Chen M (共同作者), Zheng T, Su W, Wang J, Yang Z, Park R, Dagliyan G, Conti PS, Brand D, Liu Z, Zou H, Stohl W, Zheng SG*. Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells. Ann Rheum Dis. 2012 Sep;71(9):1567-72.    (IF=9.111)

        9.      Chen M, Guo Z, Ju W, Ryffel B, He X, Zheng SG. The development and function of follicular helper T cells in immune responses. Cell Mol Immunol. 2012 Sep;9(5):375-9.      (IF=3.419)

        10.  Lan Q, Zhou X, Fan H, Chen M, Wang J, Ryffel B, Brand D, Ramalingam R, Kiela PR, Horwitz DA, Liu Z*, Zheng SG*. Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome. J Mol Cell Biol. 2012 Dec;4(6):409-19.    (IF=7.308)

        11.  Xu W, Lan Q, Chen M, Chen H, Zhu N, Zhou X, Wang J, Fan H, Yan CS, Kuang JL, Warburton D, Togbe D, Ryffel B, Zheng SG*, Shi W*. Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. PLoS One. 2012;7(7):e40314.    (IF=3.73)

        12.  Su W, Fan H, Chen M, Wang J, Brand D, He X, Quesniaux V, Ryffel B, Zhu L, Liang D*, Zheng SG*. Induced CD4+ forkhead box protein-positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-β1. J Allergy Clin Immunol. 2012 Aug;130(2):444-52.e7.   (IF=12.047)

        13.  Kong N, Lan Q, Chen M, Wang J, Shi W, Horwitz DA, Quesniaux V, Ryffel B, Liu Z, Brand D, Zou H*, Zheng SG*. Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum. 2012 Aug;64(8):2548-58.  (IF=7.477)

        14.  Lu L, Ma J, Li Z, Lan Q, Chen M, Liu Y, Xia Z, Wang J, Han Y, Shi W, Quesniaux V, Ryffel B, Brand D, Li B, Liu Z, Zheng SG*. All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus. PLoS One. 2011; 6(9):e24590.    (IF=3.73)

        15.  Chen W*,Chen M, Liao Z, Wang Y, Zhan Q, Cai G. Lymphatic vessel density as predictive marker for the local recurrence of rectal cancer. Dis Colon Rectum. 2009 Mar; 52(3):513-9.     (IF=3.336)

         

        二、近5年发表或参与发表中文论文

        1.  唐决,王东平,鞠卫强,巫林伟,陈茂根,胡安,余伟儇,何晓顺*. Genistein预处理对大鼠肝缺血再灌注损伤的保护作用. 中国普通外科杂志, 2011, 20(1):53-57

        2.  陈维荣*, 陈茂根, 蔡高阳, 廖梓群. 微淋巴管密度对直肠癌手术远端切除长度的临床意义. 中华胃肠外科杂志, 2008 Mar;11(2):136-40.  

        3.  廖梓群,陈维荣*,蔡高阳,陈茂根,詹庆华. D2-40标记的微淋巴管密度与直肠癌淋巴转移的关系. 汕头大学医学院学报, 2008, 21(04):212-214  

        4.  陈茂根,陈维荣*,蔡高阳,庄潮平,李廷汉,廖梓群. 淋巴管内皮透明质酸受体-1在直肠癌中的表达及其意义. 中国普通外科杂志, 2007, 16(9):906-909

        5.  陈茂根,陈维荣*. 微淋巴管与肿瘤预后及治疗的研究进展. 国际外科学杂志, 2007, 34(9):631-634

         

        三、会议论文

        1.      Chen, MG; He, XS; Zheng, SG. Gingiva-Derived Mesenchymal Stem Cells-Mediated Therapeutic Intervention for Experimental Arthritis. ARTHRITIS AND RHEUMATISM, 2011, 63(10): S442-S443. reference abstract: 1135.  ---- 75th Annual Scientific Meeting of the American-College-of-Rheumatology/46th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, Chicago, IL. NOV 04-09, 2011.

        2.      Zheng, SG; Chen, MG ; Su, WR; Wang, JL; Brand, D; Ryffel, B; He, XS; Le, A. Gingiva-derived mesenchymal stem cells-mediated therapeutic intervention for experimental arthritis through Foxp3+Tregs. J Immunol, May 2012, 188 (Meeting Abstract Supplement) 56.7.  ---- 99th Annual Meeting of the American-Association-of-Immunologists, Boston, MA. MAY 04-08, 2012.

        3.      Ju, WQ; Guo, ZY; He, XS; Chen, MG; Deng, RH. Combined 'En Bloc' Liver-Duodeno-Pancreatic Transplantation in Patients with End-Stage Liver Disease and Type 2 Diabetes Mellitus. LIVER TRANSPLANTATION, 2012, 18(S1):S245-S245. ---- 18th Annual International Congress on ILTS, San Francisco, CA. MAY 16-19, 2012.

        4.      Zheng, Song Guo; Chen, Maogen; Chen, Dong Dong; Gu, Jian; Shen, Y. Human Gingiva-Derived Mesenchymal Stromal Cells Inhibit Graft-Versus-Host Disease Through CD39 and IDO. ARTHRITIS AND RHEUMATISM, 65(SI): S789-S789. ----77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals. San Diego, CA. OCT 25-30, 2013 

        5.      Zheng, Song Guo; Gu, Jian; Chen, Maogen; Shen, Yi. Gingival Stem Cells Suppress Osteoclast Formation and Bone Erosion In CIA Through CD39 Signal. ARTHRITIS AND RHEUMATISM, 65(SI): S945-S945. 77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals. San Diego, CA. OCT 25-30, 2013

        6.      Zheng, Song Guo; Chen, Maogen; Li, Qiang; Stohl, William. BAFF Promotes T Follicular Helper Cell Development and Germinal Center Generation In Mice. ARTHRITIS AND RHEUMATISM, 65(SI): S306-S306. 77th Annual Meeting of the American-College-of-Rheumatology / 48th Annual Meeting of the Association-of-Rheumatology-Health-Professionals. San Diego, CA. OCT 25-30, 2013

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